Anne Bang, Ph.D.

anne bang

Anne Bang, Ph.D.

Director, Cell Biology

Anne Bang's Research Focus

Phenomena or Processes > Cell Biology, Embryonic/Pluripotent Stem Cells, Neurogenesis, Neurodegeneration, Development and Differentiation, Development of Neuronal Circuits, Neurogenesis, Synaptic Transmission, Synapse Function, Synapse Formation and Maturation, Neuron-Glia Interactions in Myelin, Neurobiology, Neurodegeneration, Neurotransmitters
Techniques and Technology > Molecular Genetics, High Content Imaging, Fluorescence Microscopy, Electrophysiology, Cellular and Molecular Imaging, Drug Discovery, In vivo Modeling, Microarrays
Related Diseases > Neurodegenerative and Neuromuscular Diseases, Alzheimer's Disease, Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease), Congenital Disorders of Glycosylation, Glycosylation-Related Disorders, Multiple Sclerosis, Muscular Dystrophy, Aging-Related Diseases
Research Models > Human Embryonic Stem Cells, Human Cell Lines, Human Adult/Somatic Stem Cells

Dr. Anne Bang is an experienced cell biologist and stem cell expert who leads efforts at the Prebys Center to develop patient cell specific and human induced pluripotent stem cell (hiPSC)-based disease models for drug screening and target identification. Her research program is primarily focused on neurological and neuromuscular disease, with the aim of designing human cell based models and assays that reflect higher order cellular functions and recapitulate disease phenotypes, yet have the throughput and reproducibility required for drug discovery. Towards this goal her group has worked to develop a suite of foundational high throughput assays to monitor neuronal morphology, mitochondrial function, and electrophysiology, using high content screening, and multi-electrode array formats. They have conducted high-throughput drug screens on muscular dystrophy patient cells, hiPSC-derived cardiomyocytes, and hiPSC-derived neurons, including from Alzheimer’s patient specific hiPSC. Anne is a principal investigator for the National Institute of Mental Health (NIMH) National Cooperative Reprogrammed Cell Research Groups consortium “iPSC-based platform development for major psychiatric disorder modeling and discovery", and also receives research support from rare disease foundations and pharma sponsored collaborations.

Anne Bang's Research Report

Selected Publications
 

Vannoy, C.H., H. Zhou, C. Qiao, X. Xiao, A.G. Bang*, Qi L. Lu* 2016. AAV-Mediated Mini-Agrin Delivery is Unable to Rescue Disease Phenotype in a Mouse Model of Limb Girdle Muscular Dystrophy Type 2I. American Journal of Pathology, in press,(*corresponding authors).

Bardy C., M. Van Den Hurk, C. March and, T. Eames, R. Hernandez, M. Kellogg, M. Gorris, B. Galet, V. Palomares, J. Brown, A.G. Bang, J. Mertens, L. Boehnke, L. Boyer, S. Simon, F. H. Gage. 2015. Neuronal medium supporting physiological synaptic activity and fundamental functions of human neurons in vitro. Proc Natl Acad Sci, 112(20):E2725-34.

Schulz T., H.Y. Young, A.D. Agulnick, J. Babin, E.E. Baetge, A.G. Bang, A. Bhoumik, et al. 2012. A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells. PLoS One 7(5):e37004. Epub 2012 May 18.

Kelly O.G., M.Y. Chan, L.A. Martinson, K. Kadoya, T. Ostertag, K. Ross, M. Richardson, M.K. Carpenter, K.A. D’Amour, E. Kroon, M. Moorman, E.E. Baetge, and A.G. Bang. 2011. Novel surface markers for the isolation and transplantation of pancreatic cells derived from human embryonic stem cells. Nat Biotechnol., Jul 31;29(8):750-6.

Bang A.G. and M.K. Carpenter. 2009. Characteristics and characterization of human pluripotential stem cells. In Essentials of Stem Cell Biology, 2nd Edition, ed. Robert Lanza, Academic Press.

Bang A.G. and M.K. Carpenter. 2008. Deconstructing pluripotency. Commentary. Science 320 (5872):58-9.

Kroon E., L. A. Martinson, K. Kadoya, A.G. Bang, O.G. Kelly, S. Eliazer, H. Young, M. Richardson, N.G. Smart, J. Cunningham, A.D. Agulnick, D'Amour KA, M.K. Carpenter & E.E. Baetge. 2008. Pancreatic endoderm derived from human embryonic stem cells generates glucose responsive insulin-secreting cells in vivo. Nat Biotechnol., 26(4):443-52.

D'Amour K.A,. A.G. Bang, S. Eliazer, O.G. Kelly, A.D. Agulnick, N.G. Smart, M.A. Moorman, E. Kroon, M.K. Carpenter & E.E. Baetge. 2006. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol., 24(11):1392-401.

Patents
 

Jackson, M., and Bang, A.G. 2013. Theranostics platform and methods of use, Patent Application No. PCT/US13/26448, Sanford Burnham Medical Research Institute, La Jolla, CA.

Kelly, O.G., and Bang, A.G. 2012. Methods for purifying endoderm and pancreatic endoderm cells from human embryonic stem cells, United States Patent 8,338,170, ViaCyte, Inc., San Diego, CA.

D'Amour K., Bang A., Baetge, E. 2012. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production. United States Patent 8,129,182, ViaCyte, Inc., San Diego, CA.

Green, C., Yu X., Bang A., Brandon, E., Kelly, O., Agulnick, A., Baetge, E., D'Amour K., Schulz, T., Robins, A. 2011. Stem cell aggregate suspension compositions and methods of differentiation thereof. United States Patent 8,008,075, ViaCyte, Inc., San Diego, CA.

 

Anne Bang's Bio

Dr. Bang has over 20 years of experience in the fields of developmental and stem cell biology. She obtained a B.S. degree from Stanford University, a Ph.D. in Biological Sciences from the University of California, San Diego, and did postdoctoral training in the Neurobiology Laboratory at the Salk Institute for Biological Sciences. Thematically, her thesis and postdoctoral studies focused on molecular mechanisms that regulate neurogenesis and patterning in the developing nervous system. Anne’s experience in stem cell biology began in 2005 when she joined ViaCyte, Inc. where she served as Director of Stem Cell Research and managed an interdisciplinary group working to develop human embryonic stem cells (hESC) as a replenishable source of pancreatic cells for the treatment of diabetes. Her efforts focused on optimization of the differentiation process, and then on advancing the cell therapy product into development, scaled manufacturing, product characterization, and safety assessment. Anne is a co-inventor on multiple ViaCyte patents, and her team’s contributions played a key role in securing a $20 MM California Institute of Regenerative Medicine (CIRM) Award. In June of 2010, SBP recruited Anne as Director of Cell Biology to lead efforts in stem cell-based disease modeling at the Conrad Prebys Center for Chemical Genomics. Her role includes leading internal research projects, as well as external collaborations with academic and industry partners. She is an internship mentor for the CIRM Bridges to Stem Cell Research Program, and serves on advisory boards for multiple biotechnology companies.

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Publications

Kelly OG, Chan MY, Martinson LA, Kadoya K, Ostertag TM, Ross KG, Richardson M, Carpenter MK, D'Amour KA, Kroon E, Moorman M, Baetge EE, Bang AG
Nat Biotechnol 2011 Jul 31;29(8):750-6
Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, Gage FH
Proc Natl Acad Sci U S A 2015 May 19;112(20):E2725-34
Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C
Neuron 2017 Apr 5;94(1):48-57.e4
Liu R, Chen R, Elthakeb AT, Lee SH, Hinckley S, Khraiche ML, Scott J, Pre D, Hwang Y, Tanaka A, Ro YG, Matsushita AK, Dai X, Soci C, Biesmans S, James A, Nogan J, Jungjohann KL, Pete DV, Webb DB, Zou Y, Bang AG, Dayeh SA
Nano Lett 2017 May 10;17(5):2757-2764
Stern S, Santos R, Marchetto MC, Mendes AP, Rouleau GA, Biesmans S, Wang QW, Yao J, Charnay P, Bang AG, Alda M, Gage FH
Mol Psychiatry 2017 Feb 28;