Brooke Emerling, Ph.D.

Brooke Emerling's Research Focus

Breast Cancer, Cancer
Cancer Biology, Cancer Metabolism, Cell Signaling, Metabolic Processes, Signal Transduction

Research in the Emerling Lab is focused on understanding key signaling and metabolic pathways involved in the regulation of cellular function under pathological conditions such as cancer. Our research program centers around dissecting the roles of the family of non-canonical phosphatidylinositol kinases, called the phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks), in cancer metabolism using a multi-disciplinary approach integrating human, mouse, and worm models. Currently, a major research project in the Emerling Lab is determining the role of the PI5P4Ks in p53 mutant cancers, especially the triple-negative breast cancer subgroup where targeted therapies have not been effective.

Brooke Emerling's Bio

Emerling received her B.A. from the University of California Santa Cruz and her Ph.D. in molecular and cellular biology from Northwestern University. Emerling did her postdoctoral training at Harvard Medical School. She then became an Instructor of Cancer Biology in Medicine at Weill Cornell Medical College in New York City, where she continued her research on lipid kinase signaling and cancer metabolism. In August 2016, Brooke joined the faculty at SBP Medical Discovery Institute as an Assistant Professor in the Cancer Metabolism and Signaling Networks Program.

 

Funding Awards and Collaborative Grants

  • Breast Cancer Research Foundation - AACR Career Development Award for Translational Breast Cancer Research
  • Mary Kay Foundation Innovative Translational Grant Award
  • Department of Defense Breast Research Program Breakthrough Award
     

Honors and Recognition

  • AACR – Aflac Travel Fellowship Award (2013) 
  • Mastercard Ajay Banga Scientist Award (2013-2016) 
  • NextGen Star – AACR Early-Career Speaker Award (2014)
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Publications

Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM
Mol Cell 2018 May 3;70(3):531-544.e9
Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT
Mol Cell 2016 Jan 21;61(2):187-98
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
Cell 2013 Nov 7;155(4):844-57
Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM
Mol Cell 2018 May 3;70(3):531-544.e9
Palamiuc L, Emerling BM
J Exp Med 2018 Jan 2;215(1):17-19
Ravi A, Emerling BM
Mol Cell 2017 Nov 2;68(3):471-472