Chris Larson, Ph.D.

Chris Larson headshot

Chris Larson, Ph.D.

Adjunct Associate Professor

Chris Larson's Research Focus

Cancer, Cardiovascular Diseases, Diabetes - General, Heart Disease, Immune Disorders, Infectious Diseases, Metabolic Diseases, Aging-Related Diseases, Arthritis, Atherosclerosis, Breast Cancer, Cardiomyopathies, Congenital Disorders of Glycosylation, Hypertension, Inflammatory/Autoimmune Disease, Metabolic Syndrome, Monogenic Diabetes, Muscular Dystrophy, Obesity, Ovarian Cancer, Peripheral Vascular Disease, Psoriasis, Sarcopenia/Aging-Related Muscle Atrophy, Stroke, Type 1 Diabetes, Type 2 Diabetes, Vitamin Deficiency, Transcription Factors, Biochemistry
G-Protein Coupled Receptors, Glucose Transport, Insulin Secretion, Insulin Signaling, Metabolic Networks, Metabolic Processes, Metabolic Signaling, Protein Structure-Function Relationships, Adipocyte Differentiation, Adipogenesis, Aging, Angiogenesis, Calcium Signaling, Cancer Biology, Cancer Metabolism, Cardiovascular Biology, Cell Signaling, Cellular Senescence, Combinatorial Therapies, Cytokines, Disease Therapies, Exercise, Fuel Metabolism, Gene Regulation, Glycosylation, Hunger Regulation, Incretins, Inflammation, Kinase Inhibitors, Mitochondrial Biology, Nuclear Hormone Receptors, Phosphorylation, Regenerative Biology, Serine/Threonine Kinases, Signal Transduction, TNF-Family, Transcriptional Regulation, Vascular Remodeling, VEGF Signaling
Cell Biology, Drug Discovery, Biophysics, Calcium Imaging, Chemical Biology, Drug Delivery, High Content Imaging, High-Throughput/Robotic Screening, In vivo Modeling, Metabolomics, Pharmacogenomics, Pharmacology, Pharmacokinetics, Small Molecule Compounds
Heart, Cardiovascular System, Adipose Tissue, Endocrine System, Gastrointestinal System, Hepatopancreatic System, Immune System and Inflammation, Liver, Musculoskeletal System, Pancreas, Respiratory System, Vasculature
Clinical and Transitional Research, Organic and Synthetic Chemistry, Bacteria, Cultured Cell Lines, Human, Human Adult/Somatic Stem Cells, Human Cell Lines, Human Embryonic Stem Cells, Mouse, Mouse Cell Lines, Mouse Embryonic Stem Cells, Mouse Somatic Stem Cells, Primary Cells, Primary Human Cells, Primate, Purified Macromolecules, Rat

Dr. Larson's scientific interests are unified by matching deep understanding of the etiology and pathophysiology of unmet medical needs to the predicted consequences of target biology modulation. His recent drug discovery research efforts focus on ameliorating the metabolic, energy balance, and ion activity and transport deficits in highly respiring tissues that underlie numerous poorly treated cardiovascular and metabolic diseases.

Chris Larson's Bio

Before joining SBP, Dr. Chris Larson spent six years at Takeda Pharmaceuticals, where he advanced numerous candidate drugs from research to global clinical development. His most recent position at Takeda was US head, and associate global head, of cardiovascular and metabolic diseases drug discovery, in which role he expanded the company’s US research enterprise into several new disease areas, introduced new drug and therapeutic modalities into the global cardiovascular and metabolic diseases portfolio, and pioneered an open innovation academic collaboration program and a Bioenergetics Center of Excellence at the research facilities in San Diego.

Prior to Takeda, Chris held research positions of increasing responsibility at several private and public biotechnology companies. Earlier in his career, Chris helped launch and grow Karus Therapeutics, a biotechnology company based in Southampton, England, that focused on two innovative classes of small molecule cancer drugs. Prior to that, he led discovery research projects and oversaw translation of the first clinical program at Kemia, Inc., a small biotech in San Diego.

Chris earned his B.A. and Ph.D. in chemistry from Carleton College and Harvard University, respectively, and did postdoctoral research at the Salk Institute in Cancer Biology.

Chris’s lifetime professional goal is to participate in the creation of a novel drug that saves and extends healthy lives, and to help others do the same.

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Larson CJ, Verdine GL
Nucleic Acids Res 1992 Jul 11;20(13):3525
Potter DA, Larson CJ, Eckes P, Schmid RM, Nabel GJ, Verdine GL, Sharp PA
J Biol Chem 1993 Sep 5;268(25):18882-90
Dyer MA, Naidoo R, Hayes RJ, Larson CJ, Verdine GL, Baron MH
Mol Cell Biol 1996 Mar;16(3):829-38
Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum JL, Olefsky JM, Lee YS
Mol Metab 2018 Dec 2;
Riopel M, Seo JB, Bandyopadhyay GK, Li P, Wollam J, Chung H, Jung SR, Murphy A, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Koh DS, Larson CJ, Olefsky JM, Lee YS
J Clin Invest 2018 Apr 2;128(4):1458-1470
Tcholakov I, Grimshaw CE, Shi L, Kiryanov A, Murphy ST, Larson CJ, Plonowski A, Ermolieff J
Biosci Rep 2017 Jun 30;37(3)