Maximiliano D'Angelo's Research Focus
A hallmark of eukaryotic cells is that the genome is enclosed by the Nuclear Envelope (NE), a double lipid bilayer that physically separates the nuclear interior from the cytoplasm. The NE is penetrated by large multiprotein channels known Nuclear Pore Complexes or NPCs. Historically, NPCs were considered static structures whose main and only function was to control the exchange of molecules between the nucleus and the cytoplasm. But this simplistic view of the NPC is now changing, as it has become evident that NPCs are highly dynamic complexes with many transport-independent functions such as chromatin organization, gene expression regulation and the control of cell fate. The main focus of our laboratory is to study the role of nuclear pore complexes in nuclear organization, cell differentiation, aging and disease.
Maximiliano D'Angelo's Bio
Dr. D’Angelo earned his B.S. and M.S. degrees in chemistry at the University of Cordoba, Argentina, and his Ph.D. in biochemistry and molecular biology from University of Buenos Aires. He then trained as a postdoctoral fellow in cell biology at The Salk and the Scripps Research Institute in San Diego. In 2011, Dr. D’Angelo was appointed as an Assistant Professor of the Biochemistry and Biophysics department and a Principal Investigator of the Cardiovascular Research Institute at the University of California San Francisco. In 2012, he was named Scholar of the Pew Charitable Trust. Dr. D’Angelo was recruited the to the Development, Aging and Regenerative Program at SBP in October 2014.
Funding Awards and Collaborative Grants
Pew Charitable Trust Scholar in Biomedical Sciences