Pier Lorenzo Puri, M.D., Ph.D.

Pier Lorenzo Puri's Research Focus

Muscular Dystrophy, Cancer

Puri’s lab group investigates the molecular mechanism underpinning genome reprogramming during cell lineage commitment and terminal differentiation of embryonic and adult stem cells, and during induced pluripotency.

The Puri lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in embryonic and adult stem cells. The lab is especially interested in skeletal muscle progenitors, and one area of focus is how deregulated gene expression in these cells leads to development of rhabdomyosarcoma (RMS).

We have a specific interest in the mechanism by which the cues released within the regenerative environment are converted by intracellular signaling into the epigenetic information that controls gene expression in muscle stem cells and other cellular components of their niche.

Our area of investigation include:

  1. the impact of regeneration cues on the ability of muscle progenitors to proliferate and differentiate into skeletal myofibers
  2. the discovery of pharmacological interventions that promote muscle regeneration to repair diseased muscles, and in particular dystrophic muscles
  3. the ability of extracellular signal-activated kinases to influence the assembly of chromatin-associated complexes that regulate gene transcription during cellular regeneration, differentiation, and neoplastic transformation
  4. the epigenetic networks that regulate embryonic stem cell commitment toward different lineages and induced pluripotency in somatic cells
  5. the mechanism that maintains the genomic integrity in differentiation-committed cells exposed to genotoxic agents
  6. the molecular relationship between DNA damage, terminal differentiation and senescence during organismal aging.

Pier Lorenzo Puri's Bio

Pier Lorenzo Puri earned his M.D. at the University of Rome “la Sapienza” in 1991. Dr. Puri completed his internship in Internal Medicine at the hospital "Policlinico Umberto I" (Rome) from 2002 to 2007, and earned his Ph.D. at the University of Rome “la Sapienza” in 1997. During this time he was frequently working at the Freien University of Berlin, as visiting scientist. Dr. Puri trained as a post-doctoral fellow at the University of California San Diego (UCSD), in the department of Cell Biology, under the supervision of Dr. Wang, from 1997 to 2001. He was appointed as Staff Scientist at the Salk Institute (La Jolla) in 2001, and became an Assistant Telethon Scientist at the Dulbecco Telethon Institute in Rome in 2002. He was upgraded to Associate Telethon Scientist at the Dulbecco Telethon Institute in Rome since 2007. Dr. Puri joined SBP as an Assistant Professor in 2004. He has been promoted to Associate Professor in 2010. Since 2008 Dr. Puri is Adjunct Professor of Pediatrics at the University of California, San Diego and Associate Member of Sanford Children’s Health Research Center (Muscle Development and Regeneration program).


University of Rome La Sapienza, Undergraduate, Internal Medicine
University of Rome La Sapienza, M.D., Internal Medicine
University of Rome La Sapienza, Ph.D., Internal Medicine
University of California San Diego, Postdoctoral, Department of Biology

Other Appointments

Associate Scientist, Dulbecco Telethon Institute, Roma, Italy 
Associate Adjunct Professor, Department of Pediatrics, UCSD 
Associate Member, Sanford Children’s Health Research Center

DAR Accessory


Wang L, Zhang X, Guo Y, Chen X, Li R, Liu L, Shi C, Guo C, Zhang Y
Cell Physiol Biochem 2010;26(6):1093-102
Innocenzi A, Latella L, Messina G, Simonatto M, Marullo F, Berghella L, Poizat C, Shu CW, Wang JY, Puri PL, Cossu G
EMBO Rep 2011 Feb;12(2):164-71
Palacios D, Mozzetta C, Consalvi S, Caretti G, Saccone V, Proserpio V, Marquez VE, Valente S, Mai A, Forcales SV, Sartorelli V, Puri PL
Cell Stem Cell 2010 Oct 8;7(4):455-69
Iannotti FA, Pagano E, Guardiola O, Adinolfi S, Saccone V, Consalvi S, Piscitelli F, Gazzerro E, Busetto G, Carrella D, Capasso R, Puri PL, Minchiotti G, Di Marzo V
Nat Commun 2018 Sep 27;9(1):3950
Coenen-Stass AML, Sork H, Gatto S, Godfrey C, Bhomra A, Krjutškov K, Hart JR, Westholm JO, O'Donovan L, Roos A, Lochmüller H, Puri PL, El Andaloussi S, Wood MJA, Roberts TC
Mol Ther Nucleic Acids 2018 Aug 17;13:1-15
Malecova B, Gatto S, Etxaniz U, Passafaro M, Cortez A, Nicoletti C, Giordani L, Torcinaro A, De Bardi M, Bicciato S, De Santa F, Madaro L, Puri PL
Nat Commun 2018 Sep 10;9(1):3670