Yingjun Zhao's Research Focus
Yingjun Zhao's Research Report
Dr. Zhao’s research is focused on the intracellular trafficking of key receptors and secretases involved in neurodegeneration, and regulatory aspects underlying Aβ processing from the β-amyloid (Aβ) precursor protein. At present, his research interests encompass tau cleavage/neurofibrillary tangle formation, Aβ-induced synaptic dysfunction and microglial activation in Alzheimer’s disease onset.
Dr. Zhao has characterized a novel pathway (appoptosin/caspase-3/cleaved tau) which is causal to the pathogenesis of tauopathies such as Alzheimer’s disease and progressive supranuclear palsy. Recently, he identified TREM2 as an Aβ receptor, which regulates microglia-mediated Aβ clearance and Aβ-induced microglial activation. These studies provide novel therapeutic targets/strategies for Alzheimer’s disease and other tauopathies. Dr. Zhao’s research is supported by the BrightFocus Foundation, Tanz family fund, and NIH.
Yingjun Zhao's Bio